Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Benefits of Self-Esteem01:25

Benefits of Self-Esteem

192
Self-esteem—an individual's overall evaluation of their worth—plays a complex role in psychological functioning and well-being. It is often associated with many positive traits, such as confidence, optimism, and perseverance. Individuals with high self-esteem typically experience better sleep, manage peer pressure more effectively, and report greater life satisfaction. Conversely, low self-esteem has been consistently linked with increased risks of depression, anxiety, and poor...
192
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

755
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
755
Heart Valves01:16

Heart Valves

11.4K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
11.4K
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

425
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
425
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

488
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
488

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parenteral clomipramine for depression or obsessive-compulsive disorder: a systematic review and meta-analysis.

Acta neuropsychiatrica·2026
Same author

Clinical benefits and risks of remote patient monitoring: an overview and assessment of methodological rigour of systematic reviews for selected patient groups.

BMC health services research·2025
Same author

Benefits and risks of using laparoscopic ultrasonography versus intraoperative cholangiography during laparoscopic cholecystectomy for gallstone disease: a systematic review and meta-analysis.

Surgical endoscopy·2024
Same author

Child and maternal benefits and risks of caseload midwifery - a systematic review and meta-analysis.

BMC pregnancy and childbirth·2023
Same author

Safety, effectiveness, women's experience, and economic costs of outpatient induction in women with uncomplicated pregnancies: A systematic review and meta-analyses.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2022
Same author

Term breech presentation-Intended cesarean section versus intended vaginal delivery-A systematic review and meta-analysis.

Acta obstetricia et gynecologica Scandinavica·2022

Related Experiment Video

Updated: Jan 23, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

26.3K

[Severe COPD can benefit from endobronchial valves].

Gerdt Riise1, Therese Svanberg2, Ola Samuelsson3

  • 1Sahlgrenska universitetssjukhuset - Lungmedicin Goteborg, Sweden - Respiratory Medicine Gothenburg, Sweden.

Lakartidningen
|June 14, 2019
PubMed
Summary

Endobronchial valves (EBV) offer significant lung function and quality of life improvements for emphysema patients when placed unilaterally. However, this treatment also increases the risk of serious complications like pneumothorax.

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

785
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.3K

Related Experiment Videos

Last Updated: Jan 23, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

26.3K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

785
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.3K

Area of Science:

  • Pulmonology
  • Interventional Pulmonology
  • Respiratory Medicine

Background:

  • End-stage COPD and emphysema present significant challenges for patient management.
  • Lung volume reduction is a key strategy for managing severe respiratory conditions.
  • Endobronchial one-way valves (EBV) represent an innovative approach to lung volume reduction.

Purpose of the Study:

  • To evaluate the efficacy and safety of endobronchial valves (EBV) for lung volume reduction in severe emphysema.
  • To compare unilateral versus bilateral EBV placement in patients with emphysema.
  • To assess the impact of EBV treatment on lung function, quality of life, physical capacity, and mortality.

Main Methods:

  • Systematic review and meta-analysis of nine randomized controlled trials (RCTs).
  • Studies focused on patients with severe emphysema undergoing EBV insertion.
  • Comparison between EBV treatment and optimal medical therapy, analyzing unilateral and bilateral approaches.

Main Results:

  • Unilateral EBV placement showed clinically significant improvements in lung function, quality of life, and physical capacity compared to optimal medical therapy.
  • No significant differences in mortality were observed between EBV treatment and optimal medical therapy.
  • The incidence of serious complications, particularly pneumothorax, was higher with EBV treatment.
  • Bilateral EBV treatment did not yield comparable improvements in the studied outcome variables.

Conclusions:

  • Unilateral endobronchial valve (EBV) therapy is an effective treatment for selected patients with severe emphysema, improving key functional and quality-of-life metrics.
  • While effective, unilateral EBV placement is associated with an increased risk of adverse events, necessitating careful patient selection and monitoring.
  • Bilateral EBV application did not demonstrate significant benefits, suggesting unilateral treatment is currently the preferred approach for this intervention.