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Updated: Jan 23, 2026

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
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Evaluation of Post-operative Meningitis: Comparison of Meningitis Caused by Acinetobacter spp. and Other Possible

Gonul Cicek Senturk1, Rafet Ozay, Gulnur Kul

  • 1Diskapi Yildirim Beyazit Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey.

Turkish Neurosurgery
|June 14, 2019
PubMed
Abstract

Insights

Postoperative meningitis (POM) caused by Acinetobacter spp. has a high mortality rate, especially when empirical treatment is inappropriate. Early identification and targeted treatment are crucial for improving outcomes in these critical neurosurgical infections.

Area of Science:

  • Neurosurgery
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Postoperative meningitis (POM) is a serious complication following craniotomy.
  • Acinetobacter spp. are increasingly recognized as challenging pathogens in healthcare-associated infections.

Purpose of the Study:

  • To analyze POM after craniotomy.
  • To compare clinical characteristics, treatment, and mortality of POM caused by Acinetobacter spp. versus other pathogens.

Main Methods:

  • Retrospective review of 112 POM cases (2008-2016).
  • Cases categorized into Acinetobacter spp. meningitis, non-Acinetobacter bacterial meningitis, and culture-negative meningitis.
  • Comparison of demographic, clinical, laboratory, treatment, and mortality data.

Main Results:

  • Acinetobacter spp. identified in 45% of bacterial meningitis cases.
  • Mortality was significantly higher in the Acinetobacter group (55.6%) compared to other groups (24.2% and 24%).
  • Isolation of Acinetobacter spp. and inappropriate treatment were independent risk factors for mortality.

Conclusions:

  • Postoperative meningitis due to Acinetobacter spp. is associated with high mortality.
  • Inappropriate empirical treatment significantly increases mortality risk.
  • Effective management requires prompt diagnosis and targeted antimicrobial therapy.

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