Related Experiment Video
Updated: Jan 23, 2026
Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
Interactive functions of microRNAs in the miR-23a-27a-24-2 cluster and the potential for targeted therapy in cancer
Mengying Cui1, Xiaoxiao Yao1, Yang Lin1
1Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, P. R. China.
Abstract:
MicroRNAs (miRNAs) are small noncoding RNAs about 19-22 nucleotides in length. Growing evidence has reported the significant role of miRNAs in various cancer-associated biological processes, such as proliferation, differentiation, apoptosis, metabolism, invasion, metastasis, and drug resistance. However, most studies focus on the targets of some individual miRNAs; the interactive and global functions of diverse miRNAs are still unclear and the phenomenon of the gathering of miRNAs in clusters has always been ignored. On the other hand, the fact that a single miRNA may regulate many genes and that numerous mRNAs are regulated by the same miRNA also makes it imperative to further study the cooperating characteristics of miRNAs in cancer. MiR-23a-27a-24-2 is located in the human chromosome 9q22, forming three mature miRNAs: miR-23a, miR27a, and miR-24, which are expressed abnormally in many malignant tumors. This review aims to summarize the interactive functions of miRNAs in miR-23a-27a-24-2 clusters in cancer from the perspectives of the regulation network, tumor microenvironment, and targeted therapy.
Insights
MicroRNAs (miRNAs) are crucial in cancer, but their collective roles are understudied. This review explores the interactive functions of the miR-23a-27a-24-2 cluster in cancer biology and therapy.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression.
- miRNAs play significant roles in cancer development and progression.
- The interactive functions and cluster-specific roles of miRNAs in cancer remain underexplored.
Purpose of the Study:
- To review the interactive functions of the miR-23a-27a-24-2 cluster in cancer.
- To explore the cluster's role in regulatory networks, tumor microenvironment, and targeted therapy.
Main Methods:
- Literature review focusing on the miR-23a-27a-24-2 cluster.
- Analysis of miRNA interactions and functions in various cancers.
- Synthesis of information on regulatory networks, tumor microenvironment, and therapeutic implications.
Main Results:
- The miR-23a-27a-24-2 cluster miRNAs (miR-23a, miR-27a, miR-24) are frequently dysregulated in malignant tumors.
- These miRNAs exhibit complex interactions and cooperative functions in cancer.
- The cluster influences cancer-associated biological processes and the tumor microenvironment.
Conclusions:
- Understanding the cooperative functions of miRNA clusters like miR-23a-27a-24-2 is vital for cancer research.
- This cluster presents potential as a biomarker and therapeutic target in oncology.
- Further investigation into miRNA cluster interactions can advance cancer treatment strategies.
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
01:22MicroRNAs
01:22MicroRNAs
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:23Holter Monitor: 24-Hour Monitoring
02:57piRNA - Piwi-interacting RNAs