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Updated: Jan 23, 2026

Infant Auditory Processing and Event-related Brain Oscillations
Published on: July 1, 2015
Brief resolved unexplained events in infants
1John P. Bastin is an assistant professor and clinical education director in the PA program at Florida State University College of Medicine in Tallahassee, Fla., and practices in the ED at Jackson Hospital in Marianna, Fla. The author has disclosed no potential conflicts of interest, financial or otherwise.
Insights
Brief resolved unexplained events (BRUE) in infants can be frightening. This review covers the AAP
Area of Science:
- Pediatrics
- Neonatal Medicine
- Emergency Medicine
Background:
- Brief resolved unexplained events (BRUE), previously termed apparent life-threatening events (ALTE), cause significant parental anxiety.
- Accurate diagnosis and risk stratification are crucial for appropriate infant management.
Purpose of the Study:
- To review the American Academy of Pediatrics' clinical criteria for diagnosing BRUE.
- To outline recommendations for evaluating infants who meet low-risk criteria for BRUE.
Main Methods:
- Literature review of current guidelines and evidence.
- Analysis of the American Academy of Pediatrics' clinical criteria for BRUE.
Main Results:
- The article details the specific diagnostic criteria for BRUE.
- It provides a framework for risk assessment in infants presenting with BRUE.
Conclusions:
- Adherence to standardized criteria can improve diagnostic accuracy for BRUE.
- Appropriate evaluation of low-risk infants can prevent unnecessary interventions and reduce healthcare costs.
Abstract:
Brief resolved unexplained events in infants (BRUE, formerly called apparent life-threatening events) can be terrifying for parents. This article reviews the American Academy of Pediatrics' clinical criteria for BRUE and recommendations for evaluating infants who meet low-risk criteria for BRUE.
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