Related Experiment Video
Updated: Jan 23, 2026
A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
Published on: August 28, 2014
Gelatin-Collagen Nonwoven Scaffold Provides an Alternative to Suprathel for Treatment of Superficial Skin Defects
Jennifer L Schiefer1, Rebekka Rath, Manuel Held
1At the time this article was written, at the Clinic of Plastic, Reconstructive, Hand and Burn Surgery, Eberhard Karls University, Tuebingen, Germany, Jennifer L. Schiefer, MD, was a resident; Rebekka Rath was a medical student; Manuel Held, MD, was a resident; Wiebke Petersen was a medical student; Jan-Ole Werner was a medical student; and Hans-Eberhard Schaller, MD, was Director. Afshin Rahmanian-Schwarz, MD, was Director, Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, Helios Clinic, University of Witten/Herdeke, Germany.
Objective:
To evaluate the effect of a new biologic gelatin-collagen nonwoven scaffold compared with a more common synthetic wound dressing on the healing of superficial wounds.
Methods:
Three superficial wounds with a depth of 0.5 mm and a length of 2.4 cm were created on the flanks of six minipigs using a skin dermatome. One wound on each pig was treated with the new nonwoven scaffold, one with the more common synthetic wound dressing, and one functioned as an untreated control wound. All three wounds were then covered with a semipermeable, sterile, transparent film.
Results:
After 7 days, complete wound closure of all wounds could be detected; epidermal thickness and the number of epidermal cells of all treated wounds were significantly increased compared with the control wounds. The nonwoven dressing showed slightly better results compared with the more common dressing.
Conclusions:
The nonwoven scaffold is an interesting and competitive material for promoting epidermal wound healing. Because it is a biologic dressing, it degenerates completely and does not have to be removed from the wound. Further research should be conducted to compare this new dressing with other currently available wound treatments.
Related Concept Videos
02:18Alternative RNA Splicing
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
02:18Alternative RNA Splicing
01:11Fibril-associated Collagen
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
01:23Lumber Defects
Shakes are minor fractures that run along or across the wood's annual rings, while wane is...
01:16Null and Alternative Hypotheses
The null hypothesis, denoted by H0 is a statement of no difference between the variables—they are not related. This can often be considered the status quo. As a result if you cannot accept the null, it requires some action.
The alternative hypothesis, denoted by H1 or Ha, is a claim about the...
01:25Electric Generator: Alternator
The magnetic flux passing through the coil varies sinusoidally as the loop rotates inside the magnetic field. This...