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Related Experiment Videos

Norplant contraceptive implants: rods versus capsules.

S A Pasquale1, V Brandeis, R I Cruz

  • 1Department of Obstetrics & Gynecology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903-0019.

Contraception
|September 1, 1987
PubMed
Summary

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Norplant contraceptive implants, containing levonorgestrel, provide highly effective, long-term birth control with minimal pregnancy risk. Irregular bleeding was the main side effect but was well-tolerated, showing low discontinuation rates.

Area of Science:

  • Reproductive Health
  • Contraception
  • Pharmacology

Background:

  • Norplant contraceptive implants utilize levonorgestrel-releasing silastic rods for sustained contraception.
  • Subcutaneous placement in the upper arm ensures consistent, low-level hormone release over time.

Purpose of the Study:

  • To compare the efficacy and side effect profiles of a two-rod versus a six-capsule Norplant system.
  • To evaluate the safety and tolerability of levonorgestrel implants for long-term contraception.

Main Methods:

  • A comparative study involving 250 subjects over 4,464 months of use.
  • Assessment of pregnancy rates, side effects, and discontinuation rates for both Norplant systems.

Main Results:

Keywords:
BiologyComparative StudiesContraceptionContraception ContinuationContraception FailureContraceptive AgentsContraceptive Agents, FemaleContraceptive Implants--side effectsContraceptive Methods--side effectsContraceptive UsageDemographic FactorsDiseasesFamily PlanningFertilityGenital Effects, FemaleGenitaliaGenitalia, FemaleMenstruation DisordersMethod AcceptabilityPhysiologyPopulationPopulation DynamicsReproductive BehaviorResearch MethodologyStudiesUrogenital EffectsUrogenital System

Related Experiment Videos

  • Only one pregnancy occurred across all subjects, demonstrating high contraceptive efficacy.
  • Irregular uterine bleeding was the most common side effect but was generally well-tolerated.
  • Discontinuation rates were very low for both the two-rod and six-capsule systems.

    • Conclusions:

    • Norplant contraceptive implants offer a highly effective and well-tolerated long-term contraception method.
    • The two-rod system presents advantages in insertion and removal compared to the six-capsule system.
    • Norplant implants are suitable for women seeking reliable contraception and may gain wide acceptance globally.