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The relative bioavailability of levonorgestrel and ethinylestradiol when administered in tablet and capsule form
D J Back1, S R Killick, P J Stevenson
1Department of Pharmacology and Therapeutics, University of Liverpool.
Contraception
|September 1, 1987
Abstract:
The relative bioavailability of levonorgestrel (LNG) and ethinylestradiol (EE2) administered as a conventional tablet (150/30) or capsule has been assessed in a randomized two-period crossover study in 9 healthy volunteer women. Serum concentrations were monitored for 24h post-dosing. There was no significant difference in any of the pharmacokinetic parameters determined for either steroid. Hence the relative bioavailability is similar after tablet and capsule formulations.