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Detection of Functional Matrix Metalloproteinases by Zymography
09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

84.9K

Investigation of active matrix- metaloproteinase-8 (aMMP-8) as a reference parameter for path control in

J Deumer1, M Frentzen2, M C Meinke3

  • 1MVZ Erstes Zahnärztliches Lasercentrum Berlin, Gatower Straße 296, 14089 Berlin, Germany.

Heliyon
|June 14, 2019
PubMed
Abstract

Insights

Antimicrobial photothermal therapy (aPTT) combined with scaling and root planing (SRP) significantly reduced active matrix-metalloproteinase-8 (aMMP-8) levels and periodontal pocket depth more than SRP alone. This indicates a enhanced immune response in periodontal disease treatment.

Area of Science:

  • Periodontology
  • Biomaterials Science
  • Laser Dentistry

Background:

  • Chronic periodontal disease is characterized by inflammation and tissue destruction.
  • Active matrix-metalloproteinase-8 (aMMP-8) is a key biomarker for periodontal disease activity.
  • Current treatments like scaling and root planing (SRP) aim to reduce bacterial load and inflammation.

Purpose of the Study:

  • To evaluate the influence of active matrix-metalloproteinase-8 titer (aMMP-titer) on the immune response.
  • To compare monotherapy SRP with SRP combined with antimicrobial photothermal therapy (aPTT, Emundo®).

Main Methods:

  • Retrospective, monocentric, randomized, split-mouth study design.
  • Twenty patients with chronic periodontal disease (PPD 4-8 mm, PSI > 3, recession ≤2 mm) were included.
  • Diode laser (810 nm) with EmunDo® photothermic dye was used for aPTT, combined with SRP on specific teeth, compared to SRP monotherapy on contralateral teeth.

Main Results:

  • Both treatment groups showed a reduction in aMMP-8 titer and periodontal pocket depth after one month.
  • The combination of SRP with aPTT demonstrated a significantly more pronounced decrease in aMMP-8 titer and periodontal pocket depth compared to SRP monotherapy.
  • aMMP-8 levels differed between groups pre- and post-treatment.

Conclusions:

  • Antimicrobial photothermal therapy (aPTT) in conjunction with SRP enhances the reduction of periodontal disease markers.
  • aMMP-8 serves as an acceptable reference parameter for monitoring treatment efficacy in aPTT.
  • The findings support aPTT as an effective adjunct therapy for periodontal disease.
Keywords:
Dentistry

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