Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ixodes dammini: salivary anti-complement activity.

J M Ribeiro1

  • 1Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts 02115.

Experimental Parasitology
|December 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world safety and effectiveness of neoadjuvant chemotherapy combination with pembrolizumab in triple-negative breast cancer.

ESMO real world data and digital oncology·2026
Same author

Pathological complete response with neoadjuvant pembrolizumab and chemotherapy in non-metastatic triple-negative inflammatory breast cancer.

ESMO open·2026
Same author

Urban wastewater treatment plants as resource hubs: evaluating circularity and sustainability of nutrient recovery and water reuse.

Water research·2025
Same author

Towards circular desalination: A new methodology for measuring and assessing resource flows and circular actions.

Water research·2025
Same author

Knowledge of gross human anatomy among Brazilian physical education students: A cross-sectional study.

Morphologie : bulletin de l'Association des anatomistes·2025
Same author

Moving to ultra-short therapy to cure patients with cancer: a solution for sustainable cancer care.

ESMO open·2024
Same journal

Morphological and infection responses of Psoroptes ovis var. cuniculi to Metarhizium pingshaense and peppermint-based compounds.

Experimental parasitology·2026
Same journal

Exploring polyporphyrin isolated from Carica papaya seed oil in the control of Anopheles gambiae (Diptera: Culicidae) () mosquito.

Experimental parasitology·2026
Same journal

Trypanocidal activity of nanoemulsion loaded with triterpene 3β,6β,16β-trihydroxylup-20(29)-ene from Combretum leprosum against Trypanosoma cruzi Y strain.

Experimental parasitology·2026
Same journal

Nanotechnology in the management of neglected protozoan diseases: Current advances, translational challenges, and future prospects.

Experimental parasitology·2026
Same journal

Corrigendum to "Expression profiling of GP63 isoforms with predicted nuclear localization signals in Leishmania (Viannia) braziliensis" [Experimental Parasitology 286 (2026) 109155].

Experimental parasitology·2026
Same journal

Identification of ZINC database-derived antitrypanosomal candidates targeting Trypanosoma congolense lysosomal-α-mannosidase using computational, biochemical and in vivo methods.

Experimental parasitology·2026
See all related articles

Tick saliva from Ixodes dammini inhibits the human complement system, preventing red blood cell breakdown. This salivary anti-complement factor, with a molecular weight of 49,000, aids tick feeding.

Area of Science:

  • Immunology
  • Parasitology
  • Biochemistry

Background:

  • The complement system is crucial for innate immunity.
  • Ticks, like Ixodes dammini, possess mechanisms to evade host immune responses during feeding.

Purpose of the Study:

  • To investigate the anti-complementary activity of Ixodes dammini saliva.
  • To characterize the component in tick saliva responsible for inhibiting complement activation.

Main Methods:

  • Hemolysis assays using rabbit erythrocytes and human alternative complement pathway.
  • Gel filtration chromatography to determine molecular weight of the inhibitor.

Main Results:

  • Ixodes dammini saliva inhibits hemolysis mediated by the human alternative complement pathway.

Related Experiment Videos

  • Saliva prevents C3b deposition and C3a release, crucial steps in complement activation.
  • Inhibition is effective across various mammalian serum sources.
  • The anti-complementary activity is attributed to a factor with an estimated molecular weight of 49,000.

    • Conclusions:

    • Ixodes dammini saliva contains a potent anti-complement factor.
    • This salivary component likely facilitates tick feeding by subverting host complement defenses.
    • The identified inhibitor may be a target for understanding host-parasite interactions.