Related Experiment Video
Updated: Jan 23, 2026

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
Published on: December 8, 2023
Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation
Claudio I Perez1,2, Ying Han1, Jennifer Rose-Nussbaumer1,3
1Department of Ophthalmology, University of California, San Francisco, CA, USA.
Purpose:
To report two cases of neurotrophic keratitis (NK) after micropulse transscleral cyclophotocoagulation (MP-TCP).
Observations:
Two patients with predisposing factors for decreased corneal sensation developed NK 1 month after MP-TCP. Both patients did not heal with initial treatment with topical antibiotic and preservative free artificial tears. One patient required use of a bandage contact lens and the other patient required tarsorrhaphy. Both eyes experienced recurrence of NK.
Conclusions And Importance:
NK can be triggered after MP-TCP in patients with underlying predisposing factors for decreased corneal sensation. This uncommon but vision-threatening complication should be discussed preoperatively with high-risk patients as a possible adverse event after MP-TCP and followed closely postoperatively.
Insights
Neurotrophic keratitis (NK) can occur after micropulse transscleral cyclophotocoagulation (MP-TCP), especially in patients with pre-existing corneal sensation issues. Close monitoring and preoperative discussion are crucial for managing this vision-threatening complication.
Area of Science:
- Ophthalmology
- Corneal Surgery
Background:
- Micropulse transscleral cyclophotocoagulation (MP-TCP) is a glaucoma treatment.
- Predisposing factors for decreased corneal sensation increase risk for ocular surface disease.
Observation:
- Two cases of neurotrophic keratitis (NK) developed one month post-MP-TCP.
- Patients had underlying factors for reduced corneal sensation.
- Initial treatments failed, necessitating bandage contact lens or tarsorrhaphy.
Findings:
- Neurotrophic keratitis (NK) is a potential complication following MP-TCP.
- Recurrence of NK was observed in both reported cases.
- MP-TCP may trigger NK in susceptible individuals.
Implications:
- Ophthalmologists should counsel high-risk patients about the possibility of NK after MP-TCP.
- Postoperative surveillance is essential for early detection and management of NK.
- This complication, though uncommon, can threaten vision and requires careful consideration.
Related Concept Videos
Zener Diodes
The Ideal Diode
Diode: Forward bias
The behavior of a diode in forward bias...
Modeling of Diode Forward Characteristics
Diode: Reverse bias
Small-signal Diode Model

