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Updated: Jan 23, 2026
07:54
Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Published on: August 19, 2014
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Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies
Zhenya Tang1, Guilin Tang1, Shimin Hu1
1Department of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Data in Brief
|June 14, 2019
Summary
This study details MECOM rearrangements in 129 patients, revealing diverse atypical chromosomal aberrations beyond typical translocations and inversions. Findings enhance understanding of MECOM-driven genetic alterations in disease.
Area of Science:
- Genetics
- Cytogenetics
- Molecular Biology
Background:
- MECOM rearrangements are implicated in various diseases.
- Typical chromosomal aberrations include inv(3)(q21q26.2) and t(3;3)(q21;q26.6).
Purpose of the Study:
- To analyze the spectrum of MECOM rearrangements in 129 patients.
- To characterize atypical chromosomal aberrations associated with MECOM rearrangement.
Main Methods:
- Conventional cytogenetics and fluorescence in situ hybridization (FISH).
- Karyotyping, interphase FISH, metaphase FISH, map-back FISH, and whole chromosomal painting (WCP).
Main Results:
- 129 patients with confirmed MECOM rearrangement were analyzed.
- Over 50% presented with atypical chromosomal aberrations.
- A wide spectrum of MECOM rearrangement-driven aberrations, including various translocations and insertions, were identified.
Conclusions:
- MECOM rearrangement encompasses a broad range of chromosomal abnormalities.
- Detailed cytogenetic and FISH analyses are crucial for characterizing these complex rearrangements.
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