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Related Concept Videos

Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

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Spreading of Chromatin Modifications02:25

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
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Behavior Modification01:21

Behavior Modification

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Behavioral approaches have often been criticized for ignoring mental processes and focusing solely on observable behavior. However, these approaches provide an optimistic perspective for individuals seeking to change their behaviors. Rather than concentrating on intrinsic personality traits, behavioral approaches suggest that even longstanding habits can be modified by changing the reward contingencies that maintain them.
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Protein Modifications in the RER01:26

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Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
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Surface Tension and Surface Energy01:16

Surface Tension and Surface Energy

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When a paint brush is immersed in water, the bristles wave freely inside the water. When it is taken out, the bristles stick together. The reason behind this effect is surface tension.
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Updated: Jan 23, 2026

Bio-inspired Polydopamine Surface Modification of Nanodiamonds and Its Reduction of Silver Nanoparticles
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Polydopamine-assisted surface modification for orthopaedic implants.

Luanluan Jia1,2, Fengxuan Han1,2, Huan Wang1

  • 1Department of Orthopaedic Surgery, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China.

Journal of Orthopaedic Translation
|June 14, 2019
PubMed
Summary

Polydopamine (PDA) coatings offer versatile surface modification for orthopaedic implants. These PDA-based strategies enhance cellular responses, osseointegration, and antimicrobial properties, improving implant performance and reducing failure rates.

Keywords:
ImplantsOrthopaedicPolydopamineSurface modification

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Area of Science:

  • Biomaterials Science
  • Orthopaedic Surgery
  • Surface Chemistry

Background:

  • Orthopaedic implants require surface modification to improve in vivo performance and prevent surgical failure.
  • Polydopamine (PDA) has emerged as a versatile coating material due to its adhesive properties and functional groups.
  • PDA and its derivatives are increasingly utilized for modifying inert implant surfaces.

Purpose of the Study:

  • To review recent advancements in surface modification of orthopaedic implants using polydopamine (PDA) and its derivatives.
  • To highlight the potential of PDA-based coatings in enhancing orthopaedic implant functionality.
  • To provide an overview of PDA's application in modulating cellular responses and improving implant properties.

Main Methods:

  • Review of current literature on polydopamine (PDA) applications in orthopaedic implant surface modification.
  • Analysis of PDA's ability to adhere to various substrates and immobilize biomolecules/ions.
  • Examination of PDA's role in modulating cellular behavior (spreading, migration, proliferation, differentiation).

Main Results:

  • PDA coatings can effectively modify orthopaedic implant surfaces, improving biocompatibility.
  • PDA-based modifications enhance cellular responses crucial for osseointegration.
  • PDA coatings demonstrate potential for improving osseointegration and providing antimicrobial properties.

Conclusions:

  • Polydopamine (PDA) offers a facile and versatile platform for orthopaedic implant surface modification.
  • PDA-assisted technologies show promise for enhancing orthopaedic implant function and patient outcomes.
  • The adaptability of PDA adhesion supports the development of next-generation orthopaedic implants.