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Updated: Jan 23, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Empowering Synthesis of Complex Natural Products
Lucas W Hernandez1, David Sarlah1
1Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue 270 RAL, Box 107-5, Urbana, IL, 61801, USA.
Abstract:
Synthesis of natural products remains a daring task. Their richly diverse and intricate structures often encompass a large degree of unsaturation, contain fused and/or bridged rings, or possess numerous stereogenic centers. Thus, their preparation requires significant synthetic overhead, detracting from their overall practicality as well as hampering the ability of medicinal chemists to synthesize derivatives for pharmaceutical optimization and structure-activity relationship studies. The purpose of this Minireview is to showcase recent examples of efficient total syntheses. Emphasis was not given to the evaluation of ideality or economies (quality), but rather to the practicality (quality with quantity).
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