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Increased frequency of Rh(E) in acute appendicitis
M Basta1, Z Radovanovic, C Radojicic
1Department of Pediatric Surgery, Mother and Child Health Institute, Belgrade, Yugoslavia.
Human Heredity
|January 1, 1987
Summary
The Rh(E) antigen, specifically the CcD-Ee phenotype, was more common in children with acute appendicitis. This suggests a potential genetic link, possibly polygenic, contributing to appendicitis risk.
Area of Science:
- Immunogenetics
- Pediatric Surgery
- Human Genetics
Background:
- Acute appendicitis is a common surgical emergency in children.
- Genetic factors are increasingly recognized for various diseases.
- The role of blood group antigens in appendicitis is not well-established.
Purpose of the Study:
- To investigate the association between Rh blood group antigens and acute appendicitis in a pediatric cohort.
- To explore potential genetic predispositions to acute appendicitis.
Main Methods:
- Case-control study comparing Rh antigen frequencies.
- Inclusion of 64 children with histopathologically confirmed acute appendicitis.
- Matching of control groups for ethnicity and geographic origin.
Main Results:
- A significantly higher frequency of the Rh(E) antigen was observed in children with acute appendicitis compared to controls.
- The specific Rh phenotype associated with this increase was CcD-Ee.
- Statistical analysis confirmed the high significance of this observed difference.
Conclusions:
- The findings support a hypothesis linking specific Rh blood group phenotypes to a polygenic predisposition for acute appendicitis.
- Further research into the immunogenetic basis of appendicitis is warranted.
- This study highlights a potential genetic marker for appendicitis risk in children.