Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can Systemic Treatment for Childhood Psoriasis Be Stopped in Cases of Remission? Data From the ACMe Cohort.

Pediatric dermatology·2026
Same author

Sustained efficacy of dupilumab in pediatric patients with moderate-to-severe atopic dermatitis over 1 year.

The British journal of dermatology·2026
Same author

Randomised Controlled Feasibility Trial of an Intervention to Reduce Infant Bathing.

The British journal of dermatology·2026
Same author

The worldwide burden of skin diseases: Lessons from the Global Burden of Disease data.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Author Correction: Atopic dermatitis.

Nature reviews. Disease primers·2026
Same author

Atopic dermatitis.

Nature reviews. Disease primers·2026

Related Experiment Video

Updated: Jan 23, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.1K

The exposome in atopic dermatitis.

Nicholas Stefanovic1, Carsten Flohr2, Alan D Irvine3,4

  • 1School of Medicine, Trinity College Dublin, Dublin, Ireland.

Allergy
|June 14, 2019
PubMed
Summary

The exposome, encompassing all lifetime external exposures, is crucial for understanding atopic dermatitis (AD) diversity. Research into exposomal factors and their modification offers new avenues for managing AD and other allergic conditions.

Keywords:
allergyatopic dermatitisexposomemicrobiome

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.0K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K

Related Experiment Videos

Last Updated: Jan 23, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.1K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.0K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K

Area of Science:

  • Dermatology and Environmental Health
  • Immunology and Genetics

Background:

  • Atopic dermatitis (AD) is a complex inflammatory condition influenced by genetic, immune, and environmental factors.
  • The exposome, representing lifetime external exposures, is key to understanding AD's diverse patient phenotypes.
  • The skin's direct interaction with the environment makes it a critical focus for exposomal research in AD.

Purpose of the Study:

  • To review the current understanding of exposomal influences on atopic dermatitis pathogenesis.
  • To examine mechanisms by which exposomal factors modulate AD at different time points.
  • To highlight current and future strategies for exposome modification in AD and allergic diseases.

Main Methods:

  • Narrative review of existing literature on exposome and atopic dermatitis.
  • Examination of exposomal domains: nonspecific, specific, and internal exposures.
  • Analysis of mechanisms linking exposomal factors to AD pathogenesis.

Main Results:

  • Exposomal factors significantly contribute to the phenotypic diversity observed in atopic dermatitis patients.
  • Understanding exposomal influences provides insight into AD pathogenesis across various domains.
  • Current approaches to exposome modification show promise for managing AD and other allergic conditions.

Conclusions:

  • Exposome research is vital for a comprehensive understanding of atopic dermatitis.
  • Targeting exposomal factors offers potential therapeutic strategies for AD and allergic diseases.
  • Future research should focus on novel techniques for exposome characterization and modification.