Related Experiment Video
Updated: Jan 23, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Evaluation of complete blood count parameters in cardiovascular diseases: An early indicator of prognosis?
Habib Haybar1, Seyed Mohammad Sadegh Pezeshki2, Najmaldin Saki2
1Atherosclerosis research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Insights
Complete blood count (CBC) indices like red cell distribution width (RDW) and mean platelet volume (MPV) are valuable prognostic biomarkers for cardiovascular diseases (CVDs). Inflammatory markers also aid in predicting CVD prognosis.
Area of Science:
- Hematology
- Cardiology
- Internal Medicine
Background:
- Complete blood count (CBC) indices are increasingly studied for their correlation with cardiovascular diseases (CVDs).
- Existing research on the prognostic value of CBC parameters in CVDs is dispersed.
- This review synthesizes findings on CBC indices and CVD prognosis for the first time.
Purpose of the Study:
- To review and summarize the prognostic value of CBC parameters in cardiovascular diseases.
- To consolidate dispersed research findings into a comprehensive overview.
- To highlight key CBC indices as potential biomarkers for CVD prognosis.
Main Methods:
- Literature search of English language studies from 1996-2018.
- Databases searched include Google Scholar and PubMed.
- Keywords used: "Complete blood count", "Cardiovascular disease", "Red cell distribution width", "Mean platelet volume".
Main Results:
- Red cell distribution width (RDW) is an independent prognostic biomarker for various CVDs.
- Mean platelet volume (MPV) is another significant prognostic biomarker for CVDs.
- Elevated inflammatory markers like neutrophil-to-lymphocyte ratio (NLR) indicate poor prognosis in CVD patients, particularly in myocardial infarction and heart failure.
Conclusions:
- RDW serves as a valuable independent biomarker for assessing prognosis in heart failure, atherosclerosis, and myocardial infarction.
- MPV increases are reliable prognostic and diagnostic indicators for CVDs like myocardial infarction and unstable angina.
- Inflammatory markers including white blood cell count, NLR, monocyte to HDL ratio (MHR), and platelet to lymphocyte ratio (PLR) are valuable for predicting prognosis across various CVDs.
Background:
Studies have been conducted to evaluate the correlation between complete blood count (CBC) indices and cardiovascular diseases (CVDs). Considering the dispersion of these studies as well as reports on prognostic value of CBC parameters in CVDs, we have summarized these findings as a review article for the first time.
Methods:
Relevant English language literature was searched and retrieved from Google Scholar search engine and PubMed database (1996-2018). We used "Complete blood count", "Cardiovascular disease", "Red cell distribution width", and "Mean platelet volume" as keywords.
Results:
Numerous studies indicated that red cell distribution width (RDW) is an independent prognostic biomarker in relation to CVD diseases. MPV is another considerable prognostic biomarker for CVDs. Elevations of inflammatory markers such as neutrophil to lymphocyte ratio (NLR) in CVD patients (especially in myocardial infarction and heart failure) can be considered as a factor of poor prognosis.
Conclusions:
RDW can be used as a valuable independent biomarker to investigate the prognosis of patients with heart failure (HF), atherosclerosis, myocardial infarction (MI), and other CVDs. Rapid and stable increase in MPV makes it a reliable prognostic/diagnostic parameter in CVDs such as MI and unstable angina. Among different inflammatory markers the evaluation of total white blood cell count, NLR, monocyte to high-density lipoprotein ratio (MHR) and platelet to lymphocyte ratio (PLR) may have a high value in predicting the prognosis of different CVDs including MI, HF and atherosclerosis in patients.
Related Concept Videos
01:18Cardiovascular Drugs: Classification based on Therapeutic Indications
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
02:39Indicators
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...