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Updated: Jan 23, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
The role of complement in antibody mediated transplant rejection
Joshua M Thurman1, Sarah E Panzer2, Moglie Le Quintrec3
1Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Abstract:
Antibody mediated transplant rejection (AMR) is a major cause of long-term allograft failure, and currently available treatments are of limited efficacy for treating the disease. AMR is caused by donor specific antibodies (DSA) that bind to antigens within the transplanted organ. DSA usually activate the classical pathway of complement within the allograft, and complement activation is believed to be an important cause of tissue injury in AMR. Several new clinical assays may improve our ability to identify patients at risk of AMR. Complement inhibitory drugs have also been tested in selected patients and in small series. Better understanding of the role of complement activation in the pathogenesis of AMR will likely improve our ability to diagnose the disease and to develop novel treatments.
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