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Studies on WF-3681, a novel aldose reductase inhibitor. II. Structure determination and synthesis
T Namiki1, M Nishikawa, Y Itoh
1Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
The Journal of Antibiotics
|October 1, 1987
Abstract:
The structure of WF-3681, a novel aldose reductase inhibitor produced by Chaetomella raphigera Swift No. 3681, was deduced to be 1 on the basis of its spectroscopic and chemical evidences and confirmed by a total synthesis starting from (E)-5-phenyl-4-pentenol.