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Updated: Jan 23, 2026

Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
Dysbiosis and Prematurity: Is There a Role for Probiotics?
Maria Elisabetta Baldassarre1, Antonio Di Mauro2, Manuela Capozza3
1Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. mariaelisabetta.baldassarre@uniba.it.
Abstract:
Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.
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