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The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock

Jihwan Myung1,2,3,4, Mei-Yi Wu5,6,7, Chun-Ya Lee8,9

  • 1Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei 11031, Taiwan. jihwan@tmu.edu.tw.

International Journal of Molecular Sciences
|June 15, 2019
PubMed

Insights

Chronic kidney disease (CKD) disrupts sleep by altering the kidney

Area of Science:

  • Chronobiology
  • Nephrology
  • Sleep Medicine

Background:

  • The kidney possesses a robust internal circadian clock.
  • Kidney failure is associated with disrupted sleep patterns.
  • The precise mechanisms linking kidney dysfunction to circadian disruption are unclear.

Purpose of the Study:

  • To investigate if aberrant kidney circadian rhythms contribute to sleep disturbances in chronic kidney disease (CKD).
  • To examine the impact of CKD on the kidney's circadian clock function in vivo and in vitro.
  • To explore the kidney's role in whole-body circadian timekeeping.

Main Methods:

  • Adenine-induced chronic kidney disease (CKD) model in mice.
  • Assessment of behavioral circadian rhythms.
  • In vitro analysis of kidney and suprachiasmatic nucleus (SCN) clock pacing.
  • Comparison with choroid plexus clock function.

Main Results:

  • CKD mice exhibited unstable behavioral circadian rhythms.
  • The master clock (SCN) pacing remained intact in isolated conditions.
  • The kidney clock showed reduced robustness and a prolonged period under CKD.
  • Kidney clock dysfunction in CKD is analogous to choroid plexus clock disruption.

Conclusions:

  • Aberrant kidney circadian rhythms are implicated in sleep disturbances associated with CKD.
  • The kidney functions as a significant peripheral clock influencing whole-body circadian timing.
  • Disruption of the kidney clock may impact the central circadian pacemaker, affecting sleep-wake cycles.
Keywords:
CKDSCNcircadian clockshierarchical organizationkidneysystemic clocks

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