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Updated: Jan 23, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Loss to follow-up 1 year after lower extremity peripheral vascular intervention is associated with worse survival
Grace J Wang1, Dejah R Judelson2, Philip P Goodney3
11 Hospital of the University of Pennsylvania, Division of Vascular Surgery, Philadelphia, PA, USA.
Insights
Loss to follow-up (LTF) in lower extremity peripheral vascular intervention (PVI) patients is linked to poorer outcomes and reduced survival. Improving follow-up strategies is crucial for better patient survival rates.
Area of Science:
- Vascular Surgery
- Health Outcomes Research
Background:
- Loss to follow-up (LTF) is a known predictor of adverse outcomes post-procedure.
- Understanding patient characteristics and factors influencing LTF is vital for improving care.
Purpose of the Study:
- To identify differences between patients undergoing lower extremity peripheral vascular intervention (PVI) with and without LTF.
- To determine the impact of LTF on patient survival after PVI.
Main Methods:
- Analysis of 39,342 patients from the Vascular Quality Initiative (VQI) PVI registry.
- Utilized t-test, chi-squared, multivariable logistic regression, and Cox regression analyses.
- Compared outcomes and survival rates between patients with and without LTF.
Main Results:
- The 1-year follow-up rate was 91.6%.
- LTF patients were more likely to be male, Hispanic, Black, and have comorbidities like diabetes, coronary artery disease, congestive heart failure, and dialysis dependence.
- LTF was associated with critical limb ischemia, urgent interventions, higher postoperative complications, lower technical success, and decreased survival.
Conclusions:
- Significant demographic and clinical differences exist between PVI patients with and without LTF.
- LTF is independently associated with decreased survival, with face-to-face follow-up linked to longer survival.
- Targeted strategies are needed to enhance follow-up rates and improve long-term survival in PVI patients.
Abstract:
Loss to follow-up (LTF) has been associated with worse outcomes after procedures. We sought to identify differences in lower extremity peripheral vascular intervention (PVI) patients with and without LTF, and to determine if LTF impacted survival. Patients in the PVI registry of the Vascular Quality Initiative (VQI) were included (n = 39,342), where t-test and chi-squared analysis were used to compare those with and without LTF. Multivariable logistic regression was used to identify factors associated with LTF while Cox regression analysis was applied to compare survival among those with and without LTF. The overall 1-year follow-up rate was 91.6%. LTF patients were more often male, Hispanic, of black race, and had a higher rate of diabetes, coronary artery disease, congestive heart failure, and dialysis. LTF patients had a higher prevalence of critical limb ischemia, underwent popliteal or distal intervention, and were intervened upon urgently. There was also a higher rate of postoperative complications, and a lower rate of technical success for LTF patients. After controlling for center effects, the independent variables associated with LTF included male sex, age, diabetes, dialysis dependence, ASA class 3 or greater, as well as complications requiring admission. Preoperative aspirin, preadmission home living status, prior carotid intervention, and discharge aspirin were protective against LTF. Adjusted survival analysis showed decreased survival in LTF, with those returning face-to-face surviving longer than those with phone follow-up. Efforts should be focused on understanding these differences to improve follow-up rates and help improve overall survival.
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