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Updated: Jan 23, 2026
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An In Vitro Model to Study the Effect of 5-Aminolevulinic Acid-mediated Photodynamic Therapy on Staphylococcus aureus Biofilm
Published on: April 16, 2018
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CASSETTE-clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: study protocol for a
Ravindra Dotel1,2, Steven Y C Tong3,4, Asha Bowen5,6
1Centre for Infectious Diseases and Microbiology, Westmead Hospital, University of Sydney, Sydney, Australia. ravindra.dotel@health.nsw.gov.au.
Trials
|June 15, 2019
Summary
This study investigates clindamycin's effect on severe Staphylococcus aureus infections. Adding clindamycin may improve patient outcomes by reducing toxin production and inflammation.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Pharmacology
Background:
- Staphylococcus aureus exotoxins are key virulence factors.
- Clindamycin, an antibiotic inhibiting protein synthesis, is hypothesized to reduce exotoxin production and improve severe S. aureus infection outcomes.
- Randomized prospective data supporting clindamycin's efficacy in severe S. aureus infections are currently limited.
Purpose of the Study:
- To assess the impact of adjunctive clindamycin on patient-centered outcomes in severe, toxin-mediated Staphylococcus aureus infections.
- To evaluate the feasibility of a larger randomized controlled trial (RCT) based on pilot study results.
Main Methods:
- An open-label, multicenter, randomized controlled trial (RCT) comparing standard treatment with standard treatment plus 7 days of clindamycin.
- Inclusion of at least 60 adult and pediatric participants with severe S. aureus infections (septic shock, necrotizing pneumonia, multifocal infections) within 72 hours of culture.
- Primary outcome: days alive and free of systemic inflammatory response syndrome (SIRS) within 14 days. Secondary outcomes include mortality, SIRS resolution, microbiological failure, and C-reactive protein changes.
Main Results:
- Pilot study data will inform feasibility for a larger RCT.
- Analysis will include impacts of inducible clindamycin resistance, strain types, methicillin susceptibility, and exotoxin presence.
Conclusions:
- This pilot RCT will provide crucial data on the effectiveness of adjunctive clindamycin in severe S. aureus infections.
- Findings will guide future, larger-scale trials to establish clindamycin's role in managing these critical infections.
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