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Updated: Jan 23, 2026

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
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High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Published on: January 19, 2022

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Cost-effectiveness analysis of three algorithms for diagnosing primary ciliary dyskinesia: a simulation study

Panayiotis Kouis1,2,3, Stefania I Papatheodorou4,5, Nicos Middleton6

  • 1Respiratory Physiology Laboratory, Medical School, University of Cyprus, Nicosia, Cyprus. kouis.panayiotis@ucy.ac.cy.

Orphanet Journal of Rare Diseases
|June 15, 2019
PubMed
Summary

Diagnosing Primary Ciliary Dyskinesia (PCD) is more effective using a parallel testing approach with nasal Nitric Oxide (nNO), High-Speed Video Microscopy (HSVM), and Transmission Electron Microscopy (TEM). This combined method identifies more patients cost-effectively compared to sequential testing strategies.

Keywords:
Cost-effectiveness analysisDecision analysis Kartagener syndromeDiagnosisHigh speed video microscopyNitric oxidePrimary ciliary dyskinesiaTransmission Electron microscopy

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