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Laparoscopic versus open distal pancreatectomy (LAPOP): study protocol for a single center, nonblinded, randomized
Bergthor Björnsson1, Per Sandström2, Anna Lindhoff Larsson2
1Department of Surgery and Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. bergthor.bjornsson@liu.se.
Trials
|June 15, 2019
Summary
Laparoscopic distal pancreatectomy (LDP) may offer shorter hospital stays than open distal pancreatectomy (ODP). The LAPOP trial is investigating this benefit, comparing recovery times and other outcomes for patients undergoing LDP versus ODP.
Area of Science:
- Minimally Invasive Surgery
- Surgical Oncology
- Gastrointestinal Surgery
Background:
- Nonrandomized studies suggest laparoscopic distal pancreatectomy (LDP) offers advantages over open distal pancreatectomy (ODP) in hospital stay, blood loss, and recovery.
- Limited randomized evidence exists, with one study indicating faster functional recovery after LDP.
Purpose of the Study:
- To test the hypothesis that LDP reduces postoperative hospital stay compared to ODP.
- To evaluate secondary outcomes including functional recovery, bleeding, complications, pain management, and quality of life.
Main Methods:
- The LAPOP trial is a prospective, randomized, nonblinded, parallel-group, single-center superiority trial.
- Sixty patients with resectable pancreatic body or tail lesions will be randomized to LDP or ODP.
- Primary outcome is postoperative hospital stay; secondary outcomes include functional recovery, bleeding, complications, and quality of life.
Main Results:
- Data collection and analysis are ongoing as part of the LAPOP trial.
- Specific results regarding the primary and secondary outcomes are not yet available.
Conclusions:
- The LAPOP trial aims to provide definitive evidence on the superiority of LDP over ODP in terms of hospital stay.
- Findings will inform clinical practice regarding the optimal surgical approach for distal pancreatectomy.
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