Pregnancies after IVF when high tonic LH is reduced by long-term treatment with GnRH agonists

Some patients show high output of urinary LH when superovulated with clomiphene citrate and HMG. Recent evidence has shown that this is detrimental to successful IVF. By the use of an GnRH analogue we have managed to ameliorate this condition and successfully establish pregnancy in these women. Further, the association between failure of IVF-ER and elevated levels of LH may explain the aetiology of some 'idiopathically' infertile couples.