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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
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Quantification of DTI in the Pediatric Spinal Cord: Application to Clinical Evaluation in a Healthy Patient

B B Reynolds1, S By1, Q R Weinberg1

  • 1Institute of Imaging Science (B.B.R., S.B., Q.R.W., A.A.W., A.T.N., H.R.F., B.R., S.A.S., A.B.), Vanderbilt University, Nashville, Tennessee.

AJNR. American Journal of Neuroradiology
|June 15, 2019
PubMed

Insights

Diffusion tensor imaging (DTI) indices change with age and region in the developing pediatric spinal cord. Understanding these changes in spinal cord development is crucial for future research.

Area of Science:

  • Neuroimaging
  • Developmental Biology
  • Pediatric Neurology

Background:

  • Diffusion tensor imaging (DTI) provides insights into white matter microstructural development.
  • Characterizing normal DTI indices in the pediatric spinal cord is essential for understanding development.

Purpose of the Study:

  • To characterize diffusion tensor imaging (DTI) indices in the developing pediatric spinal cord.
  • To evaluate age- and region-dependent differences in DTI indices within the spinal cord.

Main Methods:

  • Retrospective analysis of DTI data from 121 pediatric patients (0.3-18.0 years).
  • Acquisition on a 3T scanner with manual segmentation into cervical, thoracic, thoracolumbar, and conus regions.
  • Statistical analysis using ANCOVA to assess age and regional effects on DTI indices.

Main Results:

  • Significant correlations found between age and axial diffusivity, mean diffusivity, and fractional anisotropy (P < .001).
  • Significant differences observed among spinal cord regions for axial diffusivity, radial diffusivity, mean diffusivity, and fractional anisotropy (P < .001).

Conclusions:

  • Diffusion indices in the pediatric spinal cord evolve significantly with age and vary by anatomical region.
  • These findings enhance understanding of normal spinal cord development and may inform future studies on pediatric spinal pathologies.
Abstract

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