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3T MRI Whole-Brain Microscopy Discrimination of Subcortical Anatomy, Part 2: Basal Forebrain
M J Hoch1, M T Bruno2, A Faustin3
1From the Department of Radiology and Imaging Sciences, (M.J.H.), Emory University, Atlanta, Georgia.
AJNR. American Journal of Neuroradiology
|June 15, 2019
Summary
An optimized MRI sequence visualizes basal forebrain anatomy for neurosurgery. This technique improves understanding of subthalamic nucleus variations, aiding surgical targeting.
Area of Science:
- Neuroimaging
- Neuroanatomy
- Functional Neurosurgery
Background:
- The basal forebrain contains crucial structures for functional neurosurgery.
- Current MR imaging often fails to resolve this complex neuroanatomy.
Purpose of the Study:
- To demonstrate and characterize basal forebrain anatomy using an optimized TSE T2 sequence.
- To assess the utility of this protocol for functional neurosurgical applications.
Main Methods:
- Applied an optimized TSE T2 sequence to postmortem whole brain samples (n=13) on a 3T MR scanner.
- Measured subthalamic nucleus size, orientation, and position relative to the intercommissural point.
Main Results:
- Identified basal ganglia and diencephalon structures in multiple planes.
- Observed minimal right-left differences in subthalamic nucleus dimensions.
- Found significant individual variability in subthalamic nucleus angulation and position.
Conclusions:
- The TSE T2 sequence enhances visualization of basal forebrain structures for neuroradiologists.
- This protocol aids in defining individual variations for functional neurosurgical targeting.
- The method can complement advanced MR imaging techniques for in-vivo visualization.
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