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Complete Genome Sequence of emm1 Streptococcus pyogenes 10-85, a Strain Isolated from a Patient with Streptococcal

Ichiro Tatsuno1, Masanori Isaka1, Masakado Matsumoto2

  • 1Department of Bacteriology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Microbiology Resource Announcements
|June 15, 2019
PubMed

Insights

The genome of Streptococcus pyogenes strain 10-85, linked to streptococcal toxic shock syndrome, was sequenced. This strain is notable for lacking specific regulatory and restriction systems.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Streptococcus pyogenes is a significant human pathogen.
  • Streptococcal toxic shock syndrome (STSS) is a severe, life-threatening condition.
  • Understanding pathogen genomics is crucial for developing effective treatments.

Purpose of the Study:

  • To present the complete genome sequence of Streptococcus pyogenes strain 10-85.
  • To identify unique genomic features of a strain isolated from an STSS patient.

Main Methods:

  • Whole-genome sequencing of Streptococcus pyogenes strain 10-85.
  • Bioinformatic analysis to identify genomic regions and systems.

Main Results:

  • The complete genome sequence of Streptococcus pyogenes strain 10-85 (emm type 1) was determined.
  • The strain lacks the SalR-SalK two-component regulatory system.
  • The strain also lacks the adjacent type I restriction-modification system.

Conclusions:

  • The genomic data provides insights into the genetic makeup of this STSS-associated S. pyogenes strain.
  • The absence of SalR-SalK and type I restriction-modification systems may influence strain virulence or behavior.

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