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Draft Genome Sequence of FK506-Producing Streptomyces tsukubensis Strain VKM Ac-2618D

Veronika Y Poshekhontseva1,2, Eugeny Y Bragin1, Victoria V Fokina3

  • 1G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Federal Research Center, Pushchino, Russia.

Microbiology Resource Announcements
|June 15, 2019
PubMed

Insights

Researchers sequenced the genome of *Streptomyces tsukubensis* VKM Ac-2618D, the producer of tacrolimus (FK506). This macrolide is crucial for preventing organ transplant rejection and treating immune-related disorders.

Area of Science:

  • Microbiology
  • Immunology
  • Genomics

Background:

  • Tacrolimus (FK506) is a vital 23-membered macrolide immunosuppressant.
  • It is extensively used in preventing graft rejection and managing inflammatory and immune diseases.

Purpose of the Study:

  • To present the draft genome sequence of *Streptomyces tsukubensis* VKM Ac-2618D.
  • To provide genomic resources for FK506 production and strain improvement.

Main Methods:

  • Whole-genome sequencing of *Streptomyces tsukubensis* VKM Ac-2618D.
  • Bioinformatic analysis of the resulting draft genome sequence.

Main Results:

  • The draft genome sequence of the FK506-producing bacterium *Streptomyces tsukubensis* VKM Ac-2618D has been determined.
  • This provides a foundational genomic dataset for this important microorganism.

Conclusions:

  • The availability of the *Streptomyces tsukubensis* VKM Ac-2618D genome sequence facilitates further research.
  • This genomic information can aid in understanding FK506 biosynthesis and optimizing its production.

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