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ANCD thrombectomy device: in vitro evaluation.

Sonia Sanchez1, Ignacio Cortiñas1, Helena Villanova1

  • 1R&D, Anaconda Biomed, Barcelona, St Cugat del Valles, Spain.

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Summary
This summary is machine-generated.

The Advanced Thrombectomy System (ANCD) with a stent retriever achieved higher recanalization rates in fewer passes for stroke treatment. This novel device demonstrated superior preclinical efficacy in simulated middle cerebral artery occlusions.

Keywords:
devicestrokethrombectomy

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Area of Science:

  • Neuroendovascular intervention
  • Medical device technology
  • Cerebrovascular disease research

Background:

  • Endovascular therapy for stroke is effective but incomplete recanalization occurs in ~20% of cases.
  • The Advanced Thrombectomy System (ANCD) is a novel device designed to improve clot retrieval during stroke treatment.
  • ANCD aims to reduce clot fragmentation and enhance retrieval through local flow arrest and distal aspiration.

Purpose of the Study:

  • To evaluate the preclinical efficacy of the Advanced Thrombectomy System (ANCD) in combination with a stent retriever.
  • To compare the recanalization rates and efficiency of ANCD+SR against standard thrombectomy techniques.
  • To assess the device's performance in simulated middle cerebral artery occlusions using different clot compositions.

Main Methods:

  • Utilized two vascular phantoms with soft red blood cell (RBC)-rich and sticky fibrin-rich clots to model middle cerebral artery occlusions.
  • Tested three treatment strategies: balloon guide catheter + Solitaire (BGC+SR), distal access catheter + SR (DAC+SR), and ANCD+SR.
  • Recanalization rates were assessed after each pass, up to a maximum of three passes, to determine treatment success.

Main Results:

  • ANCD+SR achieved a significantly higher first-pass recanalization rate (94%) compared to BGC+SR (66%) and DAC+SR (80%).
  • The overall recanalization rate with ANCD+SR reached 100% after the final pass, remaining superior to BGC+SR (74%) and DAC+SR (90%).
  • ANCD+SR required fewer passes (mean 1.06) for complete recanalization than BGC+SR (1.46) or DAC+SR (1.25).

Conclusions:

  • In in vitro models of MCA-M1 occlusion, ANCD+SR demonstrated superior recanalization rates.
  • The ANCD+SR combination proved more efficient, achieving successful outcomes in fewer passes compared to conventional methods.
  • These findings suggest ANCD+SR is a promising advancement for endovascular stroke treatment.