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Updated: Jan 23, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
Published on: December 18, 2017
Epigenetic Factors of Disease
Ilham Alshiraihi1, Mark A Brown2,3,4,5
1Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USA. Ilham.Alshiraihi@rams.colostate.edu.
Abstract:
The development of tissues involves the direction of specific programs for gene expression among distinct cell types. These programs are often established in a heritable state by virtue of epigenetic mechanisms and corresponding pathways of cellular memory. Thus, the broad synchronization in patterns of gene expression ultimately dictates cellular consequences. Aberrations in these epigenetic mechanisms are known to be associated with a range of diseases. Herein, we highlight epigenetic factors that, when aberrantly expressed, lead to a broad range of diseases. Further, we call upon the community of biomedical researchers to share their findings related to the epigenetic factors of disease.
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