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Updated: Jan 23, 2026

Analysis of Hematopoietic Stem Progenitor Cell Metabolism
Published on: November 9, 2019
Analysis of the Complement Cascade Activation During Mobilization of Hematopoietic Stem/Progenitor Cells
Anna I Grabowska1, Jakub M Hawryluk2
1Department of Regenerative Medicine, Center for Preclinical Studies and Technology, Warsaw Medical University, Warsaw, Poland.
Abstract:
It has been shown that the complement cascade is involved in the process of mobilization of hematopoietic stem cells, from their niche in the bone marrow to the peripheral blood. Based on this knowledge modulation of complement, cascade activation may enable the development of better mobilization strategies for poorly mobilizing patients. Herein we present a mobilization protocol in mice model, useful for studying the effect of the complement activation in the mobilization process.
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