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Therapy for anogenital verrucae in preadolescent children with topical and systemic treatment

Bahir H Chamseddin1, Nnenna G Agim1, Jason Jarin2

  • 1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

Pediatric Dermatology
|June 15, 2019
PubMed

Insights

Sinecatechins 15% ointment and imiquimod 5% cream show moderate effectiveness for treating anogenital warts (AV) in children. Sinecatechins demonstrated a trend toward greater efficacy, with both treatments having mild side effects.

Area of Science:

  • Dermatology
  • Pediatric Medicine
  • Virology

Background:

  • Anogenital verrucae (AV) are common, benign human papillomavirus (HPV)-induced growths.
  • Medical treatment options for pediatric AV are not extensively studied.
  • Evaluating topical therapies for efficacy and safety in preadolescents is crucial.

Purpose of the Study:

  • To assess the efficacy and safety of sinecatechins 15% ointment and imiquimod 5% cream for treating AV in children under 12.
  • To compare the effectiveness of these topical agents when used alone or in combination with other therapies.
  • To determine the side effect profile of each treatment modality.

Main Methods:

  • Retrospective review of 37 pediatric patients with AV treated at a single institution.
  • Analysis of demographic data, treatment outcomes, and adverse events.
  • Comparison of treatment responses between sinecatechins, imiquimod, and combination therapies.

Main Results:

  • Sinecatechins showed a response in 8/9 patients (5 full, 3 partial).
  • Imiquimod showed a response in 9/17 patients (4 full, 5 partial).
  • No combination therapy demonstrated superior efficacy; side effects were mild (irritation, erythema).

Conclusions:

  • Both sinecatechins and imiquimod are moderately effective for pediatric AV treatment.
  • Sinecatechins exhibited a trend towards higher effectiveness compared to imiquimod.
  • Topical treatments offer a tolerable safety profile with low complication risk for children.
Abstract

Keywords:
anogenital wartschildrencondyloma acuminataimiquimodpreadolescentsinecatechinssystemic treatmenttopical treatment

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