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Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
12.7K
Circular RNA screening from EIF3a in lung cancer
Ma-Sha Huang1,2, Fu-Qiang Yuan1,2, Yang Gao1,2
1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P. R. China.
Cancer Medicine
|June 15, 2019
Summary
Two novel circular RNAs derived from eukaryotic translation initiation factor 3 subunit A (EIF3a) are linked to lung cancer drug sensitivity and translation regulation, offering potential therapeutic targets.
Area of Science:
- Molecular Biology
- Cancer Research
- RNA Biology
Background:
- Eukaryotic initiation factor 3 (EIF3) is a large complex involved in translation.
- EIF3a, the largest subunit, is implicated in tumorigenesis and drug resistance.
- Circular RNAs (circRNAs) are emerging as key regulators, but their functions are not fully understood.
Purpose of the Study:
- To investigate EIF3a-derived circRNAs in lung cancer.
- To identify circRNAs associated with cisplatin drug sensitivity.
- To explore the functional roles of identified circRNAs.
Main Methods:
- Screening of 31 EIF3a-derived circRNAs.
- Correlation analysis with cisplatin drug sensitivity in lung cancer.
- Bioinformatic analyses for RNA-binding protein interactions and translational regulation.
Main Results:
- Two circEIF3as were identified and correlated with cisplatin sensitivity.
- These circEIF3as are involved in RNA-binding protein processes.
- Bioinformatics suggest a role in translational regulation.
Conclusions:
- CircEIF3as are associated with lung cancer drug sensitivity and translation.
- They may act synergistically with EIF3a or serve as therapeutic targets.
- This study provides novel insights into EIF3a and circEIF3a functions in lung cancer.
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