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Updated: Jan 23, 2026

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds
Published on: August 16, 2014
[Research progress on controlled release of various growth factors in bone regeneration]
Lin Ji1, Ziwei Song2, Fuhai Zeng1
1Department of Burn and Plastic Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou Sichuan, 646000, P.R.China.
Objective:
To summarize the research progress of controlled release of angiogenic factors and osteogenic factors in bone tissue engineering.
Methods:
The domestic and abroad literature on the controlled release structure of growth factors during bone regeneration in recent years was extensively reviewed and summarized.
Results:
The sustained-release structure includes direct binding, microsphere-three-dimensional scaffold structure, core-shell structure, layer self-assembly, hydrogel, and gene carrier. A sustained-release system composed of different sustained-release structures combined with different growth factors can promote bone regeneration and angiogenesis.
Conclusion:
Due to its controllability and persistence, the growth factor sustained-release system has become a research hotspot in bone tissue engineering and has broad application prospects.
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