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Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia

Yuanzhen Xu1, Hongbo Wei1, Jinming Gao1

  • 1Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.

Mini Reviews in Medicinal Chemistry
|June 15, 2019
PubMed

Insights

Terpenoids show promise in inhibiting neuroinflammation, a key factor in diseases like Alzheimer's. This review covers research on terpenoids as potential treatments for lipopolysaccharide-induced microglial activation over the past two decades.

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Neuroinflammation, driven by activated microglia, is central to neurodegenerative diseases such as Alzheimer's and Parkinson's.
  • Overactivated microglia release harmful factors, exacerbating neuronal damage.
  • Bacterial lipopolysaccharide (LPS) is a common trigger used to study brain inflammation and its pathological mechanisms.

Purpose of the Study:

  • To review the progress of terpenoids as inhibitors of neuroinflammation.
  • To focus on studies involving LPS-stimulated BV-2 microglial cells over the last 20 years.

Main Methods:

  • Literature review of studies published in the last 20 years.
  • Focus on research investigating terpenoids' effects on LPS-induced microglial activation.
  • Analysis of terpenoids' mechanisms in modulating inflammatory responses in BV-2 cells.

Main Results:

  • Terpenoids represent a diverse group of natural compounds with demonstrated neuroinflammatory inhibitory potential.
  • Specific terpenoids have shown efficacy in reducing inflammatory markers in LPS-stimulated microglial models.
  • The last two decades have seen significant research into terpenoids for neuroinflammation.

Conclusions:

  • Terpenoids are promising candidates for developing novel neuroinflammatory inhibitors.
  • Further research is warranted to explore the therapeutic potential of terpenoids for neurodegenerative diseases.
  • Targeting microglial activation with compounds like terpenoids could offer new treatment strategies.
Keywords:
Alzheimer's diseaseNeuroinflammationParkinson's diseaselipopolysaccharidemicrogliaterpenoids

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