Related Experiment Video
Updated: Jan 23, 2026
06:45
Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
849
Are Global Health Systems Ready for Transformative Therapies?
Eric Faulkner1, Daryl S Spinner2, Moira Ringo2
1Precision and Transformative Medicine Center of Excellence, Evidera, Durham, NC, USA; Genomics Biotech and Emerging Medical Technology Institute, National Association of Managed Care Physicians, Glen Allen, VA, USA; Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Summary
Advancements in health technologies challenge current value assessment models. Global health systems struggle to recognize and reward innovation, necessitating a reconsideration of reward structures for breakthrough therapies.
Area of Science:
- Health Technology Assessment
- Innovation in Healthcare
- Value-Based Healthcare
Background:
- Significant advancements in health technologies offer transformative and curative potential.
- Global health systems face challenges in recognizing and rewarding healthcare innovation.
- Current frameworks may not adequately capture the value of novel health technologies.
Purpose of the Study:
- To examine transformative health technologies and their ecosystem effects.
- To understand challenges in assessing transformative therapies.
- To explore how health systems recognize and reward innovation.
Main Methods:
- Systematic review of 2012-2018 publications on value assessment and health system effects.
- Analysis of 100 health technology assessments (HTAs) from five markets.
- Evaluation of global sales and utilization data for patient access and commercial impact insights.
Main Results:
- Uncertainties exist regarding efficacy, safety, and duration of effect for breakthrough therapies.
- Health technology assessment (HTA) approaches varied across technology categories, despite similar safety parameter evaluations.
- Global HTA and payer systems are unprepared for emerging technology impacts on care delivery and payment models.
Conclusions:
- Rapid evolution of breakthrough therapies necessitates rethinking conventional value assessment and reward models.
- Existing health system measurement and management processes have not kept pace with technological advancements.
- Adaptation of value assessment and reward mechanisms is crucial for integrating novel health technologies.
Related Concept Videos
01:28Global Regulatory Systems
624
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
624
01:16Vector Transformation in Rotating Coordinate Systems
2.6K
Consider a vector rotating about an axis with an angular velocity, such that its tip sweeps a circular path.
2.6K
01:26Ready Mixed Concrete
353
Ready-mixed concrete, also known as pre-mixed concrete, is prepared in a centralized plant and then transported in trucks to construction sites where it is ready for placement. This type of concrete is categorized into central-mixed, truck-mixed (or transit-mixed), and shrink-mixed. Central-mixed concrete is entirely prepared at a plant and moved to the site in agitator trucks that rotate at a speed of 2 to 6 rpm. Truck-mixed concrete, on the other hand, has the ingredients batched at the plant...
353
01:50Global Climate Change
28.8K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
28.8K
01:33Bacterial Transformation
59.5K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
59.5K
01:26Transformation
750
Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
750