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[Morphological markers of liver function in alcohol intoxication]
Yu E Morozov1, V A Porodenko2, E N Travenko2
1Sechenov First Moscow State Medical University under Ministry of Health of Russia, Moscow, Russia, 119991; Bureau of Forensic Medical Expertise of the Moscow Health Department, Moscow, Russia, 115516.
This study identified new liver markers for diagnosing ethanol poisoning deaths. Researchers analyzed liver enzymes and histology in poisoning cases to understand functional changes.
Area of Science:
- Forensic Pathology
- Toxicology
- Hepatology
Background:
- Ethanol poisoning is a significant cause of mortality.
- Accurate determination of cause of death requires reliable diagnostic markers.
- Liver function is critically affected by acute ethanol intoxication.
Purpose of the Study:
- To identify novel diagnostic markers for the functional state of the liver in cases of ethanol poisoning.
- To differentiate deaths due to ethanol poisoning from other causes, such as craniocerebral injury.
- To establish quantitative indices of liver metabolic activity relevant to acute ethanol intoxication.
Main Methods:
- Histological examination of liver tissue, including assessment for steatosis, chronic hepatitis, and cirrhosis.
- Histochemical analysis of ethanol-metabolizing enzyme activity within specific liver acinar zones (Zone 1, Zone 2, Zone 3).
- Comparative analysis of liver markers in 95 acute ethanol poisoning cases and 15 craniocerebral injury cases.
Main Results:
- Quantitative indices characterizing the functional-metabolic activity of the liver during acute ethanol poisoning were obtained.
- Specific patterns of enzyme activity were observed across different acinar zones.
- Histological findings provided context for the observed biochemical changes.
Conclusions:
- The study provides new insights into liver functional changes associated with acute ethanol poisoning.
- Identified markers may aid in substantiating the cause of death in suspected ethanol intoxication cases.
- Further research can refine these markers for routine forensic application.
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