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[The question about the topical antibiotic therapy of acute rhinosinusitis]

A A Krivopalov1, S V Ryazansev1, S A Eremin1

  • 1Saint-Petersburg Institute of Ear, Nose, Throat and Speech, St.-Petersburg, Russia, 190013.

Vestnik Otorinolaringologii
|June 15, 2019
PubMed

Insights

Polydexa with phenylephrine demonstrated significant clinical efficacy in treating moderate acute rhinosinusitis. This nasal spray offers anti-inflammatory and antimicrobial benefits, improving patient outcomes and mucociliary clearance.

Area of Science:

  • Otolaryngology
  • Pharmacology

Background:

  • Moderate acute rhinosinusitis affects a significant portion of the population.
  • Current treatment often involves a combination of therapies, with a need for effective local treatments.

Purpose of the Study:

  • To evaluate the clinical efficacy and safety of Polydexa with phenylephrine as a local therapy in patients with moderate acute rhinosinusitis.
  • To compare the outcomes of using Polydexa with phenylephrine versus topical decongestants in conjunction with standard treatment.

Main Methods:

  • A randomized clinical study involving 30 patients with moderate acute rhinosinusitis.
  • Patients received systemic antibiotic therapy, nasal irrigation, and NSAIDs. The experimental group additionally received Polydexa with phenylephrine, while the control group received topical decongestants.
  • Clinical and laboratory parameters were statistically compared between the two groups.

Main Results:

  • Polydexa with phenylephrine demonstrated significant anti-inflammatory and antimicrobial effects.
  • The experimental group showed significant clinical efficacy compared to the control group.
  • The nasal spray was well-tolerated and showed a positive effect on mucociliary clearance.

Conclusions:

  • Polydexa with phenylephrine is a clinically effective and safe option for the complex treatment of moderate acute rhinosinusitis.
  • The drug's anti-inflammatory and antimicrobial properties contribute to improved patient outcomes and mucociliary function.
Keywords:
Polydexa with phenylephrineacute sinusitisantibiotic therapylocal therapyrhinosinusitis

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