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Updated: Jan 23, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Alcohol Use Disorder and Traumatic Brain Injury
Zachary M Weil1, John D Corrigan1, Kate Karelina1
1Zachary M.Weil, Ph.D., is an assistant professor in the Center for Brain and Spinal Cord Repair and Group in Behavioral Neuroendocrinology, Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio. John D. Corrigan, Ph.D., is a professor in the Department of Physical Medicine and Rehabilitation, Ohio State University Wexner Medical Center, Columbus, Ohio. Kate Karelina, Ph.D., is a research scientist in the Center for Brain and Spinal Cord Repair and Group in Behavioral Neuroendocrinology, Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio.
Abstract:
Alcohol use and traumatic brain injury (TBI) are inextricably and bidirectionally linked. Alcohol intoxication is one of the strongest predictors of TBI, and a substantial proportion of TBIs occur in intoxicated individuals. An inverse relationship is also emerging, such that TBI can serve as a risk factor for, or modulate the course of, alcohol use disorder (AUD). Critically, alcohol use after TBI is a key predictor of rehabilitation outcomes, prognosis, and additional head injuries. This review provides a general overview of the bidirectional relationship between TBI and AUD and a discussion of potential neuropsychological and neurobiological mechanisms that might underlie the relationship.
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