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Amiodarone induced epididymo-orchitis.

Neethi Dasu1, Yaser Khalid1, Sravan Panuganti2

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Amiodarone, an antiarrhythmic drug, can rarely cause epididymitis and orchitis. Discontinuing amiodarone led to symptom resolution in an elderly patient, highlighting a potential adverse effect.

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Area of Science:

  • Cardiology
  • Urology
  • Pharmacology

Background:

  • Amiodarone is a widely used antiarrhythmic medication.
  • It is known for a broad spectrum of potential side effects.
  • Rarely, amiodarone has been associated with genitourinary toxicity.

Observation:

  • An 88-year-old male patient developed testicular pain, swelling, and erythema.
  • These symptoms emerged after several years of amiodarone therapy.
  • The patient had multiple comorbidities and no prior adverse reactions to amiodarone.

Findings:

  • The patient underwent a comprehensive workup, including testicular ultrasound and consultations with urology and cardiology.
  • Discontinuation of amiodarone resulted in complete resolution of the epididymitis and orchitis symptoms.
  • The underlying mechanism for amiodarone-induced epididymitis/orchitis remains unknown.

Implications:

  • This case highlights epididymitis/orchitis as a rare but possible adverse effect of amiodarone.
  • Clinicians should consider amiodarone toxicity in patients presenting with testicular symptoms.
  • Discontinuation of the drug may be an effective management strategy.