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Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation

Xiaofeng Xu1, Haochang Hu1, Ying Lin1

  • 1Medical Genetics Center, School of Medicine, Ningbo University, Ningbo 315000, Zhejiang, China.

Biomed Research International
|June 15, 2019
PubMed

Insights

Leukocyte telomere length is significantly shorter in patients with coronary heart disease (CHD). Shorter telomeres correlate with CHD severity, particularly in Asian men and younger individuals, warranting further mechanistic research.

Area of Science:

  • Cardiovascular Research
  • Genetics
  • Aging

Background:

  • Coronary heart disease (CHD) is a leading global cause of mortality.
  • Leukocyte telomere length (LTL) has been linked to atherosclerotic disease progression and cardiovascular mortality.
  • Existing research on LTL and CHD shows inconsistent findings due to methodological variations.

Purpose of the Study:

  • To systematically evaluate the association between LTL and CHD.
  • To investigate the correlation between LTL and the severity of coronary heart disease.
  • To identify subgroups with the most pronounced LTL differences in CHD patients.

Main Methods:

  • A comprehensive literature search was conducted across five major databases: Pubmed, Web of Science, Embase, CNKI, and Wangfang.
  • Meta-analysis included 18 eligible studies comprising 5,150 CHD patients and 9,341 controls.
  • Subgroup analyses were performed based on ethnicity, age, and sex.

Main Results:

  • Patients with CHD exhibited significantly shorter LTL compared to control groups.
  • A significant inverse correlation was observed between LTL and the severity of CHD.
  • Telomere shortening was most pronounced in Asian CHD patients, those under 65 years, and male patients.

Conclusions:

  • Reduced LTL is a significant indicator associated with coronary heart disease.
  • LTL may serve as a biomarker for CHD severity and progression.
  • Further research is needed to elucidate the mechanisms linking telomere shortening to CHD pathogenesis.

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