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Ochrocephalamines B-D, Three Alkaloids from Oxytropis ochrocephala Bunge
Kang-Sheng Zhou1, Ping Yi2, Tao Yang3
1School of Ethnic Medicine , Guizhou Minzu University , Guiyang 550025 , People's Republic of China.
Abstract:
Ochrocephalamines B-D (1-3), composed of fused quinolizidine and octahydroquinoline rings, were isolated from Oxytropis ochrocephala Bunge. Ochrocephalamine B (1) has a unique bridged tetracyclic ring skeleton fused with a lactam ring. The structures of 1-3 were elucidated using spectroscopic and computational approaches. Ochrocephalamine C (2) and D (3) demonstrated potent anti-HBV activities and are more potent against the secretion of HBeAg than that of HBsAg.
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