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Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults
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When clozapine appears at a dance event….

Lisbeth Patteet1, Kristof Maudens1, Sarah Wille2

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Party drug users experienced clozapine intoxication due to misidentified tablets. Standard drug screens may miss this, necessitating specialized toxicology analysis for unusual intoxication cases.

Keywords:
Clozapineintoxicationparty drug

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Area of Science:

  • Toxicology
  • Emergency Medicine
  • Pharmacology

Background:

  • Party drugs often have unknown contents and variable dosages, increasing risks.
  • Substance abuse at events poses diagnostic challenges for medical professionals.

Observation:

  • Three individuals at a dance event presented with severe symptoms, including respiratory distress, bradycardia, syncope, and altered mental status.
  • One patient required intubation due to breathing difficulties.

Findings:

  • Blood tests confirmed clozapine intoxication, with serum concentrations below therapeutic ranges but indicative of recent intake.
  • A pill identified as clozapine (Leponex® 100 mg) was found, suggesting it was sold as a party drug.
  • Symptoms observed were consistent with clozapine's known side effects in naive individuals, even at low doses.

Implications:

  • Routine toxicology screening may fail to identify clozapine as the causative agent.
  • Unusual intoxication symptoms warrant advanced testing at a reference toxicology laboratory.
  • This highlights the danger of misidentified substances in recreational drug use and the need for better screening protocols.