Related Experiment Video
Updated: Jan 23, 2026
08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
10.6K
Taking a closer look at whole organisms.
Noriko Ichino1, Stephen C Ekker1
1Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, United States.
Elife
|June 15, 2019
Summary
X-ray histotomography allows whole zebrafish imaging at cellular resolution. This technique enhances understanding of biological variations within species.
Area of Science:
- Developmental biology
- Comparative genomics
- Biomedical imaging
Background:
- Understanding individual biological differences is crucial in biology.
- Current imaging techniques have limitations in resolving cellular details across whole organisms.
Purpose of the Study:
- To introduce and validate X-ray histotomography for whole organism imaging.
- To demonstrate its utility in studying inter-individual variation.
Main Methods:
- High-resolution X-ray imaging of whole zebrafish.
- Advanced reconstruction algorithms for 3D cellular-level visualization.
- Comparative analysis of cellular structures between zebrafish individuals.
Main Results:
- Achieved cellular resolution imaging of entire zebrafish specimens.
- Successfully visualized subtle anatomical differences at the cellular level.
- Demonstrated the feasibility of comparative analysis across multiple individuals.
Conclusions:
- X-ray histotomography provides unprecedented cellular detail for whole organisms.
- This technique is a powerful tool for investigating biological diversity.
- It will advance research into the genetic and environmental factors underlying individual differences.
Related Concept Videos
01:09Levels of Organization
139.2K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
139.2K
01:31Accessory Organs
74.0K
Accessory organs are those that participate in the digestion of food but do not come into direct contact with it like the mouth, stomach, or intestine do. Accessory organs secrete enzymes into the digestive tract to facilitate the breakdown of food.
74.0K
03:02Organic Compounds
56.8K
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
56.8K
00:53Transgenic Organisms
33.2K
Overview
33.2K
02:07Organization of Genes
73.2K
Overview
73.2K
02:18Types of Genetic Transfer Between Organisms
30.6K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
30.6K