Related Experiment Video
Updated: Jan 23, 2026

10:57
Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress
Published on: October 13, 2019
8.0K
Reading out Fisher information from the zeros of the point spread function
Optics Letters
|June 15, 2019
Summary
Superresolution imaging overcomes Rayleigh
Area of Science:
- Optical physics
- Superresolution microscopy
Background:
- Rayleigh's curse limits resolution in optical imaging.
- Point spread functions (PSFs) with zeros offer potential for improved resolution.
Purpose of the Study:
- To investigate superresolution imaging beyond Rayleigh's curse.
- To explore information gain from optical system zeros.
Main Methods:
- Theoretical analysis of information scaling with separated sources.
- Experimental demonstration using spectral doublets.
Main Results:
- Information gain scales linearly, not quadratically, with source separation near PSF zeros.
- Superresolution achieved using natural and artificial spectral doublets.
Conclusions:
- Optical system zeros enable superresolution by overcoming Rayleigh's curse.
- Spectral doublets are effective for enhanced resolution imaging.
More Related Videos
06:33Decomposing the Variance in Reading Comprehension to Reveal the Unique and Common Effects of Language and Decoding
Published on: October 11, 2018
7.2K
06:52Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
Published on: September 17, 2019
6.7K
Related Concept Videos
Behrens–Fisher Test
258
The Behrens-Fisher test is a statistical method designed to address the Behrens-Fisher problem, which arises when comparing the means of two normally distributed populations with unequal variances. Unlike the Student's t-test, which assumes equal variances, the Behrens-Fisher test allows for mean comparison without this restrictive assumption. This flexibility makes it particularly valuable in scenarios where two independent samples exhibit normality but lack variance homogeneity.
This test...
This test...
258
Complex Zeros
252
Complex zeros are the solutions to polynomial equations that include imaginary numbers, specifically, numbers of the form a + bi, where a and b are real numbers and i is the imaginary unit defined by i2=-1. These zeros satisfy the equation P(x) = 0, where P(x) is a polynomial with real or complex coefficients. Since the complex number system includes all real numbers, it provides a complete framework for analyzing all possible roots of a polynomial.Every polynomial of degree n≥1 can be...
252
Spreading of Chromatin Modifications
9.4K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
Writers
The writer...
9.4K
Fisher's Exact Test
1.2K
Fisher's exact test is a statistical significance test widely used to analyze 2x2 contingency tables, particularly in situations where sample sizes are small. Unlike the chi-squared test, which approximates P-values and assumes minimum expected frequencies of at least five in each cell, Fisher's exact test calculates the exact probability (P-value) of observing the data or more extreme results under the null hypothesis. This feature makes it especially valuable when the assumptions of...
1.2K
Uncertainty in Measurement: Reading Instruments
50.9K
Counting is the type of measurement that is free from uncertainty, provided the number of objects being counted does not change during the process. Such measurements result in exact numbers. By counting the eggs in a carton, for instance, one can determine exactly how many eggs are there in the carton. Similarly, the numbers of defined quantities are also exact. For example, 1 foot is exactly 12 inches, 1 inch is exactly 2.54 centimeters, and 1 gram is exactly 0.001 kilograms. Quantities...
50.9K
Functional Groups
87.9K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
87.9K