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Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease

Shan Tong1,2, Qingwei Ji3, Yu Du1

  • 11Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Department of Cardiology, 12th ward, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, Beijing, China.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|June 15, 2019
PubMed

Insights

Secreted frizzled-related protein-5 (Sfrp5) shows promise for improving metabolic health and combating atherosclerotic cardiovascular disease (ASCVD). This review explores Sfrp5 biology and its role in the Sfrp5/Wnt system

Area of Science:

  • Endocrinology
  • Metabolic research
  • Cardiovascular science

Background:

  • Adipose tissue is a major endocrine organ producing adipokines.
  • Few adipokines promote positive metabolism and good health.
  • Secreted frizzled-related protein-5 (Sfrp5) is an emerging adipokine with potential health benefits.

Purpose of the Study:

  • To review the biology of Sfrp5.
  • To examine the role of the Sfrp5/Wnt system in atherosclerotic cardiovascular disease (ASCVD).

Main Methods:

  • Literature review of Sfrp5 biology.
  • Analysis of Sfrp5/Wnt signaling pathways.
  • Examination of Sfrp5's impact on ASCVD.

Main Results:

  • Sfrp5 acts as a Wnt antagonist.
  • Sfrp5 exhibits favorable effects on ASCVD.
  • The Sfrp5/Wnt system is implicated in cardiovascular health.

Conclusions:

  • Sfrp5 is a significant factor in metabolic regulation.
  • Targeting the Sfrp5/Wnt pathway may offer therapeutic strategies for ASCVD.
  • Further research into Sfrp5's functions is warranted.
Keywords:
Sfrp5Wnt signaling pathwayadipokinesatherosclerotic cardiovascular disease

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