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Redox signaling in aging kidney and opportunity for therapeutic intervention through natural products

Yuan-Yuan Chen1, Xiao-Yong Yu2, Lin Chen1

  • 1School of Pharmacy, Faculty of Life Science & Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi, 710069, China.

Free Radical Biology & Medicine
|June 15, 2019
PubMed

Insights

Kidney diseases and aging impair renal function. This review explores novel therapeutic targets and highlights natural products for developing effective treatments for kidney diseases.

Area of Science:

  • Nephrology
  • Pharmacology
  • Gerontology

Background:

  • Kidney diseases pose significant public health challenges, leading to high morbidity and mortality.
  • Aging exacerbates renal dysfunction, necessitating effective interventions.
  • Current therapeutic strategies are limited by incomplete understanding of pathological mechanisms.

Purpose of the Study:

  • To review recent advances in identifying therapeutic targets for aging kidneys and kidney diseases.
  • To explore the potential of natural products in novel drug discovery for renal conditions.

Main Methods:

  • Literature review focusing on key mediators involved in kidney aging and disease.
  • Analysis of emerging therapeutic targets and natural product interventions.

Main Results:

  • Identified key mediators including nicotinamide adenine dinucleotide phosphate oxidase (NOX), transforming growth factor-β (TGF-β), renin-angiotensin system (RAS), nuclear factor-erythroid 2 related factor 2 (Nrf2), peroxisome proliferator-activated γ receptor (PPARγ), advanced glycation endproducts (AGEs), microRNAs, and vitagenes.
  • Highlighted the potential of natural products as a safe and effective source for novel therapeutic development.

Conclusions:

  • Targeting identified mediators offers promising avenues for treating kidney diseases.
  • Natural products represent a valuable resource for developing innovative treatments for renal pathologies.
Keywords:
Aging kidneyNatural productOxidative stressRedox signalingRenal diseaseTherapy target

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