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Related Experiment Video

Updated: Jan 23, 2026

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Embryonic and postnatal development of mouse olfactory tubercle.

Eduardo Martin-Lopez1, Christine Xu2, Teresa Liberia1

  • 1Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Molecular and Cellular Neurosciences
|June 15, 2019
PubMed
Summary

This study details mouse olfactory tubercle (OT) development, revealing neurogenesis from E11-E15 and a ventral migratory course. It confirms the OT

Keywords:
DevelopmentDopaminergic innervationMyelinationNeurogenesisOlfactory tubercleStriatum

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Neuroanatomy

Background:

  • The olfactory tubercle (OT) is crucial for processing olfactory behaviors, motivation, and reward, sharing traits with the striatum.
  • Despite its importance, the embryonic development and cellular phenotypes of the OT remain largely uncharacterized.

Purpose of the Study:

  • To elucidate the embryonic development and neurogenesis of the mouse olfactory tubercle (OT).
  • To characterize the migratory pathways and phenotypic properties of OT neuroblasts.
  • To detail the maturation processes, including dopaminergic innervation and myelination, within the developing OT.

Main Methods:

  • Utilized thymidine analogs to map OT neurogenesis timing and gradients.
  • Employed a piggyBac multicolor technique to trace neuroblast migration routes.
  • Analyzed molecular and cellular phenotypes using single-color piggyBac, tyrosine hydroxylase (TH) expression, and CNPase staining.

Main Results:

  • Mouse OT neurogenesis occurs predominantly between embryonic days 11-15 (E11-E15) in a lateral-to-medial gradient.
  • Identified a novel "ventral migratory course" (VMC) for OT neuroblasts originating from the ventral lateral ganglionic eminence (vLGE).
  • Demonstrated that OT neurons exhibit striatal molecular specification, with dopaminergic innervation (TH expression) beginning at E13 and myelination occurring between postnatal days 7-14 (P7-P14).

Conclusions:

  • This study provides the first comprehensive analysis of mouse OT embryonic development and maturation.
  • The findings confirm the striatal nature of the OT, classifying it as part of the ventral striatum (vST).
  • Established developmental timelines and migratory patterns provide a foundation for future research into OT function and disorders.