Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermodynamics: Chemical Potential and Activity01:10

Thermodynamics: Chemical Potential and Activity

1.7K
The effective concentration of a species in a solution can be expressed precisely in terms of its activity. Activity considers the effect of electrolytes present in the vicinity of the species of interest and depends on the ionic strength of the solution. The activity of a species is expressed as the product of molar concentration and the activity coefficient of the species.
The thermodynamic equilibrium constant is more accurately defined in terms of activity rather than concentration.
1.7K
Hybrid Zones02:29

Hybrid Zones

21.8K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
21.8K
Hybridization of Atomic Orbitals I03:24

Hybridization of Atomic Orbitals I

66.2K
The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...
66.2K
Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

48.3K
sp3d and sp3d 2 Hybridization
48.3K
Potential Energy00:52

Potential Energy

42.4K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.4K
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.0K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis.

Aesthetic plastic surgery·2024
Same author

The Causal Relationship between PCSK9 Inhibitors and Malignant Tumors: A Mendelian Randomization Study Based on Drug Targeting.

Genes·2024
Same author

Analysis of the Relation Between Balance Control Subsystems: A Structural Equation Modeling Approach.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2024
Same author

Incidence and risk of remnant gastric cancer after gastrectomy for gastric cancer: a population-based study from the SEER database.

BMC gastroenterology·2024
Same author

Differences in Physiologic Endotypes Between Nonpositional and Positional OSA: Results From the Shanghai Sleep Health Study Cohort.

Chest·2024
Same author

Mechanism-Based Inactivation of CYP2D6 by Phellopterin and Related Drug-Drug Interaction with Metoprolol.

Journal of agricultural and food chemistry·2024

Related Experiment Video

Updated: Jan 23, 2026

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
04:51

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange

Published on: June 23, 2023

4.2K

Tetrazole hybrids with potential anticancer activity.

Jingyu Zhang1, Su Wang1, Yanyan Ba1

  • 1Pharmacy College, Henan University of Chinese Medicine, 450046, Zhengzhou, PR China.

European Journal of Medicinal Chemistry
|June 15, 2019
PubMed
Summary
This summary is machine-generated.

Novel tetrazole hybrids show promise as anticancer agents, offering potential against drug-resistant cancers with reduced toxicity. This review explores their anticancer activity and structure-activity relationships for improved drug design.

Keywords:
Anticancer activityHybrid compoundsStructure-activity relationshipTetrazole

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

48.3K

Related Experiment Videos

Last Updated: Jan 23, 2026

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
04:51

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange

Published on: June 23, 2023

4.2K
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

48.3K

Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Drug Discovery

Background:

  • Cancer remains a leading global cause of death, necessitating new treatments.
  • Current chemotherapy agents often lack specificity, leading to severe side effects and the emergence of drug resistance.
  • There is a critical need for novel anticancer candidates with broad efficacy and improved safety profiles.

Purpose of the Study:

  • To review the anticancer activities of tetrazole hybrids.
  • To discuss the structure-activity relationships (SAR) of these compounds.
  • To provide insights for the rational design of more effective tetrazole-based anticancer drugs.

Main Methods:

  • Literature review of studies on tetrazole hybrids and their anticancer properties.
  • Analysis of structure-activity relationships to identify key molecular features.
  • Synthesis and evaluation of tetrazole derivatives as potential anticancer agents (implied).

Main Results:

  • Tetrazole derivatives have demonstrated significant anticancer activity.
  • Hybridization of tetrazoles with other pharmacophores enhances anticancer potency.
  • SAR studies offer guidance for optimizing the efficacy and selectivity of these agents.

Conclusions:

  • Tetrazole hybrids represent a promising class of compounds for developing new anticancer therapies.
  • Understanding SAR is crucial for designing next-generation anticancer drugs with improved activity and reduced toxicity.
  • Further research into tetrazole hybrids could lead to effective treatments for both drug-susceptible and drug-resistant cancers.